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RO 27-3225
CAS No. ——
RO 27-3225( RO27-3225 | RO 273225 )
Catalog No. M16959 CAS No. ——
RO 27-3225 (RO27-3225, RO 273225) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRO 27-3225
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NoteResearch use only, not for human use.
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Brief DescriptionRO 27-3225 (RO27-3225, RO 273225) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM.
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DescriptionRO 27-3225 (RO27-3225, RO 273225) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R; shows some activity at the MC1 receptor (EC50=8 nM), reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.Obesity Discontinued.
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In Vitro——
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In Vivo——
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SynonymsRO27-3225 | RO 273225
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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RecptorMelanocortin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight——
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCC(NC(C(NC(CC1=CC=CC=C1)C(NC(CCCNC(N)=N)C(NC(CC2C(C=CC=C3)=C3NC2)C(N(C)CC(N)=O)=O)=O)=O)=O)CC4=CNC=N4)=O
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Chemical NameButir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoracetate salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Spaccapelo L, et al. Eur J Pharmacol. 2011 Nov 30;670(2-3):479-86.
2. Minutoli L, et al. Crit Care Med. 2011 May;39(5):1089-96.
3. Benoit SC, et al. J Neurosci. 2000 May 1;20(9):3442-8.
4. Agosti F, et al. Eur J Neurosci. 2014 Sep;40(5):2755-65.
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